Control of phosphorylase activity in a muscle glycogen particle. 3. Regulation of phosphorylase phosphatase.

@article{Haschke1970ControlOP,
  title={Control of phosphorylase activity in a muscle glycogen particle. 3. Regulation of phosphorylase phosphatase.},
  author={R H Haschke and Ludwig M. G. Heilmeyer and F Meyer and E H Fischer},
  journal={The Journal of biological chemistry},
  year={1970},
  volume={245 24},
  pages={6657-63}
}
This study describes a new type of inhibition of phosphorylase phosphatase that strongly suggests that the activity of this enzyme is modulated during regulation of the phosphorylase system. Phosphorylase phosphatase included in a muscle protein-glycogen complex along with phosphorylase, phosphorylase kinase, and other enzymes of glycogen metabolism undergoes a reversible inhibition when phosphorylase is activated. This inhibition requires free Ca2f in addition to Mg-ATP, i.e. the same… CONTINUE READING