Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation.

@article{Floyd2004ControlOP,
  title={Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation.},
  author={Z. Elizabeth Floyd and Jacqueline M Stephens},
  journal={Obesity research},
  year={2004},
  volume={12 6},
  pages={921-8}
}
OBJECTIVE To determine whether small ubiquitin-related modifier (SUMO)ylation of lysine 107 plays a role in regulating the activity of peroxisome proliferator-activated receptor gamma (PPARgamma). RESEARCH METHODS AND PROCEDURES Transient expression of wild-type and K107R-PPARgamma2 in the NIH 3T3 fibroblast cell line was carried out in conjunction with half-life studies, luciferase activity assays, and indirect immunofluorescence localization studies. Additional in vitro analysis was carried… CONTINUE READING