Control of peripheral B-cell development.

  title={Control of peripheral B-cell development.},
  author={Stefano Casola},
  journal={Current opinion in immunology},
  volume={19 2},
Three subsets of mature B cells exist in mice: B-1, follicular and marginal zone B cells. The recruitment of newly formed transitional B cells into these compartments depends on signals emanating from the B-cell antigen receptor, possibly in response to (self-)antigen recognition. Recent evidence suggests that peripheral B-cell fate is controlled by B-cell antigen receptor signal strength, acting in concert with the cytokine B-cell activating factor. Other work indicates that peripheral B-cell… CONTINUE READING


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