Control of papillomavirus DNA replication and transcription.

  title={Control of papillomavirus DNA replication and transcription.},
  author={Christian Desaintes and Caroline Demeret},
  journal={Seminars in cancer biology},
  volume={7 6},
Hallmarks of HPV infection include a restricted tropism for human epithelial cells and a viral life cycle tightly linked to the differentiation program of the host keratinocyte. This particular viral cycle has hampered the study of the HPV vegetative life cycle for decades, due to the lack of suitable in-vitro culture conditions. The tissue and differentiation dependence seems to be dictated by viral transcription rather than viral DNA replication. Indeed, viral transcription is restricted to… CONTINUE READING

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