Control of pain initiation by endogenous cannabinoids

@article{Calignano1998ControlOP,
  title={Control of pain initiation by endogenous cannabinoids},
  author={A. Calignano and G. L. Rana and A. Giuffrida and D. Piomelli},
  journal={Nature},
  year={1998},
  volume={394},
  pages={277-281}
}
The potent analgesic effects of cannabis-like drugs and the presence of CB1-type cannabinoid receptors in pain-processing areas of the brain and spinal cord, indicate that endogenous cannabinoids such as anandamide may contribute to the control of pain transmission within the central nervous system (CNS). Here we show that anandamide attenuates the pain behaviour produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the CNS… Expand
975 Citations
Cannabinoid receptors and pain
  • R. Pertwee
  • Chemistry, Medicine
  • Progress in Neurobiology
  • 2001
  • 484
Pain modulation by release of the endogenous cannabinoid anandamide.
  • 466
  • PDF
Targeting the cannabinoid system for pain relief?
  • Lih-Chu Chiou, S. Hu, Y. Ho
  • Medicine
  • Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists
  • 2013
  • 42
The endocannabinoid system and pain.
  • 318
  • PDF
Interaction of the cannabinoid and opioid systems in the modulation of nociception
  • S. Welch
  • Medicine
  • International review of psychiatry
  • 2009
  • 74
Cannabinoid mechanisms of pain suppression.
  • 157
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
A second endogenous cannabinoid that modulates long-term potentiation
  • 1,360
  • PDF
Hypoactivity of the Spinal Cannabinoid System Results in NMDA-Dependent Hyperalgesia
  • 183
  • PDF
Molecular characterization of a peripheral receptor for cannabinoids
  • 4,252
The control of pain in peripheral tissue by opioids.
  • C. Stein
  • Medicine
  • The New England journal of medicine
  • 1995
  • 682
Cannabinoid receptor localization in brain.
  • M. Herkenham, A. Lynn, +4 authors K. Rice
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1990
  • 1,986
...
1
2
3
...