Control of pain initiation by endogenous cannabinoids

@article{Calignano1998ControlOP,
  title={Control of pain initiation by endogenous cannabinoids},
  author={Antonio Calignano and Giovanna La Rana and Andrea Giuffrida and Daniele Piomelli},
  journal={Nature},
  year={1998},
  volume={394},
  pages={277-281}
}
The potent analgesic effects of cannabis-like drugs and the presence of CB1-type cannabinoid receptors in pain-processing areas of the brain and spinal cord, indicate that endogenous cannabinoids such as anandamide may contribute to the control of pain transmission within the central nervous system (CNS). Here we show that anandamide attenuates the pain behaviour produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the CNS… 
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