Control of myosin-I force sensing by alternative splicing

@article{Laakso2009ControlOM,
  title={Control of myosin-I force sensing by alternative splicing},
  author={Joseph M. Laakso and John H. Lewis and H. Shuman and E. Ostap},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={107},
  pages={698 - 702}
}
Myosin-Is are molecular motors that link cellular membranes to the actin cytoskeleton, where they play roles in mechano-signal transduction and membrane trafficking. Some myosin-Is are proposed to act as force sensors, dynamically modulating their motile properties in response to changes in tension. In this study, we examined force sensing by the widely expressed myosin-I isoform, myo1b, which is alternatively spliced in its light chain binding domain (LCBD), yielding proteins with lever arms… Expand
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