Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice.

@article{Vyse1997ControlOM,
  title={Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice.},
  author={Timothy J Vyse and Stephen J. Rozzo and Charles G. Drake and Shozo Izui and Brian L. Kotzin},
  journal={Journal of immunology},
  year={1997},
  volume={158 11},
  pages={5566-74}
}
An NZB locus on distal chromosome 1 has been linked to murine lupus nephritis in backcross analyses of New Zealand mice. This locus, designated Nba2 for New Zealand Black autoimmunity 2, was found to colocalize in both (NZB x SM/J)F1 x NZW and (B6.H2z x NZB)F1 x NZB backcrosses, and was most likely situated between 92 and 97 cM from the centromere. This region of mouse chromosome 1 encodes several candidate genes, including the low affinity Fc gamma receptor genes. Both backcrosses were… CONTINUE READING

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