Control of morphology, cytoskeleton and migration by syndecan-4.

  title={Control of morphology, cytoskeleton and migration by syndecan-4.},
  author={Robert L Longley and Andrea Woods and Andrew Fleetwood and Graham Cowling and John Thomas Gallagher and John Robert Couchman},
  journal={Journal of cell science},
  volume={112 ( Pt 20)},
Syndecan-4 is a widely expressed transmembrane heparan sulfate proteoglycan which localizes to focal adhesions. Previous studies showed that the syndecan-4 cytoplasmic domain can associate with and potentiate the activity of protein kinase C, which is required for focal adhesion formation. To examine further the role of syndecan-4 in cell adhesion, we expressed syndecan-4 cDNA constructs in CHO-K1 cells. Syndecan-2 transfection was used to confirm effects seen were specific for syndecan-4… CONTINUE READING


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Elevated levels

  • F. G. Giancotti, E. Ruoslahti
  • 1990
Highly Influential
5 Excerpts

The core protein of syndecan-4 can restore focal adhesion and stress fiber formation in mutant CHO cells

  • F. Echtermeyer, P. C. Baciu, S. Saoncella, P. F. Goetinck
  • Mol. Biol. Cell 9, 57a.
  • 1998
1 Excerpt

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