Control of morphology, cytoskeleton and migration by syndecan-4.

@article{Longley1999ControlOM,
  title={Control of morphology, cytoskeleton and migration by syndecan-4.},
  author={Robert L Longley and Andrea Woods and Andrew Fleetwood and Graham Cowling and John Thomas Gallagher and John Robert Couchman},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 20)},
  pages={3421-31}
}
Syndecan-4 is a widely expressed transmembrane heparan sulfate proteoglycan which localizes to focal adhesions. Previous studies showed that the syndecan-4 cytoplasmic domain can associate with and potentiate the activity of protein kinase C, which is required for focal adhesion formation. To examine further the role of syndecan-4 in cell adhesion, we expressed syndecan-4 cDNA constructs in CHO-K1 cells. Syndecan-2 transfection was used to confirm effects seen were specific for syndecan-4… CONTINUE READING

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5 Excerpts

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