Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts

@article{Tournebize1999ControlOM,
  title={Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts},
  author={R. Tournebize and A. Popov and K. Kinoshita and A. Ashford and S. Rybina and A. Pozniakovsky and T. Mayer and C. Walczak and E. Karsenti and A. Hyman},
  journal={Nature Cell Biology},
  year={1999},
  volume={2},
  pages={13-19}
}
Microtubules are dynamic polymers that move stochastically between periods of growth and shrinkage, a property known as dynamic instability. Here, to investigate the mechanisms regulating microtubule dynamics in Xenopus egg extracts, we have cloned the complementary DNA encoding the microtubule-associated protein XMAP215 and investigated the function of the XMAP215 protein. Immunodepletion of XMAP215 indicated that it is a major microtubule-stabilizing factor in Xenopus egg extracts. During… Expand
XMAP215: a key component of the dynamic microtubule cytoskeleton.
Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis
Mini spindles, the XMAP215 homologue, suppresses pausing of interphase microtubules in Drosophila
XMAP215 regulates microtubule dynamics through two distinct domains
XMAP215 Is a Processive Microtubule Polymerase
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis
The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells.
Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 79 REFERENCES
Phosphorylation by CDK1 regulates XMAP215 function in vitro.
A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end
Accessory protein regulation of microtubule dynamics throughout the cell cycle.
  • L. Cassimeris
  • Biology, Medicine
  • Current opinion in cell biology
  • 1999
...
1
2
3
4
5
...