Control of metazoan heme homeostasis by a conserved multidrug resistance protein.

@article{Korolnek2014ControlOM,
  title={Control of metazoan heme homeostasis by a conserved multidrug resistance protein.},
  author={Tamara Korolnek and Jianbing Zhang and Simon Beardsley and George L. Scheffer and Iqbal Hamza},
  journal={Cell metabolism},
  year={2014},
  volume={19 6},
  pages={1008-19}
}
Several lines of evidence predict that specific pathways must exist in metazoans for the escorted movement of heme, an essential but cytotoxic iron-containing organic ring, within and between cells and tissues, but these pathways remain obscure. In Caenorhabditis elegans, embryonic development is inextricably dependent on both maternally derived heme and environmentally acquired heme. Here, we show that the multidrug resistance protein MRP-5/ABCC5 likely acts as a heme exporter, and targeted… CONTINUE READING
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