Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2.

@article{Zhang2012ControlOM,
  title={Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2.},
  author={Ying Zhang and R Xie and Jonathan A. R. Gordon and Kimberly E LeBlanc and Janet L Stein and Jane B Lian and Andre J van Wijnen and Gary S Stein},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 26},
  pages={21926-35}
}
Multiple microRNAs (miRNAs) that target the osteogenic Runt-related transcription factor 2 (RUNX2) define an interrelated network of miRNAs that control osteoblastogenesis. We addressed whether these miRNAs have functional targets beyond RUNX2 that coregulate skeletal development. Here, we find that seven RUNX2-targeting miRNAs (miR-23a, miR-30c, miR-34c, miR-133a, miR-135a, miR-205, and miR-217) also regulate the chondrogenic GATA transcription factor tricho-rhino-phalangeal syndrome I (TRPS1… CONTINUE READING