Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.

@article{Wang2002ControlOM,
  title={Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.},
  author={Xun Wang and John D. Crispino and Danielle L. Letting and Minako Nakazawa and M. Poncz and Gerd A Blobel},
  journal={The EMBO journal},
  year={2002},
  volume={21 19},
  pages={
          5225-34
        }
}
The transcription factor GATA-1 and its cofactor FOG-1 are essential for the normal development of erythroid cells and megakaryocytes. FOG-1 can stimulate or inhibit GATA-1 activity depending on cell and promoter context. How the GATA-1-FOG-1 complex controls the expression of distinct sets of gene in megakaryocytes and erythroid cells is not understood. Here, we examine the molecular basis for the megakaryocyte-restricted activation of the alphaIIb gene. FOG-1 stimulates GATA-1-dependent… CONTINUE READING
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