Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

  title={Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.},
  author={Maria H\oyer-Hansen and Lone Bastholm and Piotr Szyniarowski and Michelangelo Campanella and Gy{\"o}rgy Szabadkai and Thomas Farkas and K. Zwanenburg Bianchi and Nicole Fehrenbacher and Folmer Elling and Rosario Rizzuto and Ida Stenfeldt Mathiasen and Marja J{\"a}{\"a}ttel{\"a}},
  journal={Molecular cell},
  volume={25 2},
Macroautophagy is an evolutionary conserved lysosomal pathway involved in the turnover of cellular macromolecules and organelles. In spite of its essential role in tissue homeostasis, the molecular mechanisms regulating mammalian macroautophagy are poorly understood. Here, we demonstrate that a rise in the free cytosolic calcium ([Ca(2+)](c)) is a potent inducer of macroautophagy. Various Ca(2+) mobilizing agents (vitamin D(3) compounds, ionomycin, ATP, and thapsigargin) inhibit the activity of… CONTINUE READING
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