Control of mRNA decapping by autoinhibition

@inproceedings{Paquette2018ControlOM,
  title={Control of mRNA decapping by autoinhibition},
  author={David R Paquette and Ryan W Tibble and Tristan S Daifuku and John D Gross},
  booktitle={Nucleic acids research},
  year={2018}
}
5' mediated cytoplasmic RNA decay is a conserved cellular process in eukaryotes. While the functions of the structured core domains in this pathway are well-studied, the role of abundant intrinsically disordered regions (IDRs) is lacking. Here we reconstitute the Dcp1:Dcp2 complex containing a portion of the disordered C-terminus and show its activity is autoinhibited by linear interaction motifs. Enhancers of decapping (Edc) 1 and 3 cooperate to activate decapping by different mechanisms: Edc3… CONTINUE READING
8
Twitter Mentions

Figures and Topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

New insights into decapping enzymes and selective mRNA decay.

  • Wiley interdisciplinary reviews. RNA
  • 2017
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012
VIEW 11 EXCERPTS

A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5'-3' mRNA exonuclease in yeast.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2017
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL