Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition.

@article{Picker1993ControlOL,
  title={Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition.},
  author={Louis J. Picker and J R Treer and B Ferguson-Darnell and Phillip A. Collins and Dietke Buck and Leon W. M. M. Terstappen},
  journal={Journal of immunology},
  year={1993},
  volume={150 3},
  pages={1105-21}
}
Conventional virgin lymphocytes of a given class show relatively homogeneous recirculation through secondary lymphoid tissues, whereas memory/effector populations are composed of distinct subsets with differential, often tissue-selective migratory capability. In keeping with these observations, CD45RAhigh/ROlow "virgin" T cells in human peripheral blood uniformly express the peripheral lymph node homing receptor (HR) L-selectin, whereas among the CD45RAlow/ROhigh "memory/effector" subset, the… CONTINUE READING
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