Control of kinetic properties of GluR2 flop AMPA‐type channels: impact of R/G nuclear editing

@article{Krampfl2002ControlOK,
  title={Control of kinetic properties of GluR2 flop AMPA‐type channels: impact of R/G nuclear editing},
  author={Klaus Krampfl and Friedrich Schlesinger and Antje Z{\"o}rner and Martin Kappler and Reinhard Dengler and Johannes Bufler},
  journal={European Journal of Neuroscience},
  year={2002},
  volume={15}
}
The GluR2 flop subunit of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA)‐type glutamate receptors greatly determines calcium permeability and kinetic properties of heteromeric AMPA subunit assemblies. Post‐transcriptional editing of this subunit at the Q/R/N site controls calcium permeability whereas editing at the R/G site is involved in the regulation of biophysical properties. We used patch‐clamp techniques with ultrafast solution exchange to examine the kinetics of recombinant… 
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