Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands

@article{Noskov2004ControlOI,
  title={Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands},
  author={Sergei Y. Noskov and Simon Bern{\`e}che and Beno{\^i}t Roux},
  journal={Nature},
  year={2004},
  volume={431},
  pages={830-834}
}
Potassium channels are essential for maintaining a normal ionic balance across cell membranes. Central to this function is the ability of such channels to support transmembrane ion conduction at nearly diffusion-limited rates while discriminating for K+ over Na+ by more than a thousand-fold. This selectivity arises because the transfer of the K+ ion into the channel pore is energetically favoured, a feature commonly attributed to a structurally precise fit between the K+ ion and carbonyl groups… CONTINUE READING
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On the importance of atomic fluctuations, protein flexibility letters to nature NATURE |VOL

  • T. W. Allen, O. S. Andersen, B. Roux
  • J. Gen. Physiol. (in the press)
  • 2004

Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates

  • Y. F. Zhou, MacKinnon, R. The occupancy of ions in the Kþ selectivity filter
  • J. Mol. Biol. 333, 965–975
  • 2003

A simulation study

  • I. H. Shrivastava, D. P. Tieleman, P. C. Biggin, Sansom, M.S.P. Kþversus Naþ ions in a K channel selectivity filter
  • Biophys. J. 83, 633–645
  • 2002

Ion Channels of Excitable Membranes 3rd edn (Sinauer

  • B. Hille
  • Sunderland, Massachusetts,
  • 2001

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