Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands

  title={Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands},
  author={S. Y. Noskov and S. Bern{\`e}che and B. Roux},
  • S. Y. Noskov, S. Bernèche, B. Roux
  • Published 2004
  • Chemistry, Medicine
  • Nature
  • Potassium channels are essential for maintaining a normal ionic balance across cell membranes. Central to this function is the ability of such channels to support transmembrane ion conduction at nearly diffusion-limited rates while discriminating for K+ over Na+ by more than a thousand-fold. This selectivity arises because the transfer of the K+ ion into the channel pore is energetically favoured, a feature commonly attributed to a structurally precise fit between the K+ ion and carbonyl groups… CONTINUE READING
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