Control of intraocular pressure and fluctuation with fixed-combination brimonidine-timolol versus brimonidine or timolol monotherapy.

@article{Spaeth2011ControlOI,
  title={Control of intraocular pressure and fluctuation with fixed-combination brimonidine-timolol versus brimonidine or timolol monotherapy.},
  author={George L. Spaeth and Paula Bernstein and Joseph Caprioli and Rhett M Schiffman},
  journal={American journal of ophthalmology},
  year={2011},
  volume={151 1},
  pages={93-99.e4}
}
PURPOSE To evaluate control of intraocular pressure (IOP) and IOP fluctuation in patients with ocular hypertension or glaucoma treated with fixed-combination brimonidine-timolol compared with brimonidine or timolol monotherapy. DESIGN Post hoc analysis of data from 2 identical, 12-month, randomized, double-masked, multicenter trials. METHODS Patients were treated bilaterally with fixed brimonidine-timolol twice a day (n = 385), brimonidine tartrate 0.2% 3 times a day (n = 382), or timolol 0… CONTINUE READING

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