Control of intestinal inflammation by interleukin-10.

@article{Kole2014ControlOI,
  title={Control of intestinal inflammation by interleukin-10.},
  author={Abhisake Kole and Kevin J Maloy},
  journal={Current topics in microbiology and immunology},
  year={2014},
  volume={380},
  pages={
          19-38
        }
}
Twenty years ago, the observation that mice genetically deficient in IL-10 spontaneously developed severe intestinal inflammation, revealed an essential role for IL-10 in the maintenance of intestinal homeostasis. In the intervening period much has been learned about the cellular and molecular factors that are involved in IL-10-mediated regulatory pathways. Elegant experiments with conditional cell-type specific knockout strains have illustrated that IL-10 acts on both myeloid cells and T cells… CONTINUE READING
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