Control of infection by pyroptosis and autophagy: role of TLR and NLR

  title={Control of infection by pyroptosis and autophagy: role of TLR and NLR},
  author={Karina Ramalho Bortoluci and Ruslan Medzhitov},
  journal={Cellular and Molecular Life Sciences},
Cells can die by distinct mechanisms with particular impacts on the immune response. In addition to apoptosis and necrosis, recent studies lead to characterization of a new pro-inflammatory form of cell death, pyroptosis. TLR and NLR, central innate immune sensors, can control infections by modulating host cell survival. In addition, TLRs can promote the induction of autophagy, thus promoting delivery of infecting pathogens to the lysosomes. On the other hand, activation of some NLR members… 

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