Control of impurities in L-aspartic acid and L-alanine by high-performance liquid chromatography coupled with a corona charged aerosol detector.


In this study a reversed phase ion-pair high-performance liquid chromatography (HPLC) method using charged aerosol detection (CAD) was developed and fully validated for the pharmaceutical quality control of L-aspartic acid (Asp). With a slight modification, the method also allows the evaluation of related substances in L-alanine (Ala). The method enables… (More)
DOI: 10.1016/j.chroma.2009.11.036


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