Control of human potassium channel inactivation by editing of a small mRNA hairpin

@article{Bhalla2004ControlOH,
  title={Control of human potassium channel inactivation by editing of a small mRNA hairpin},
  author={Tarun Bhalla and Joshua J C Rosenthal and Miguel Holmgren and R A Reenan},
  journal={Nature Structural \&Molecular Biology},
  year={2004},
  volume={11},
  pages={950-956}
}
Genomic recoding by A→I RNA editing plays an important role in diversifying the proteins involved in electrical excitability. Here, we describe editing of an intronless potassium channel gene. A small region of human KV1.1 mRNA sequence directs efficient modification of one adenosine by human adenosine deaminase acting on RNA 2 (hADAR2). Mutational analysis shows that this region adopts a hairpin structure. Electrophysiological characterization reveals that the editing event (I/V) profoundly… 
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TLDR
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