Control of human potassium channel inactivation by editing of a small mRNA hairpin
@article{Bhalla2004ControlOH, title={Control of human potassium channel inactivation by editing of a small mRNA hairpin}, author={Tarun Bhalla and Joshua J C Rosenthal and Miguel Holmgren and R A Reenan}, journal={Nature Structural \&Molecular Biology}, year={2004}, volume={11}, pages={950-956} }
Genomic recoding by A→I RNA editing plays an important role in diversifying the proteins involved in electrical excitability. Here, we describe editing of an intronless potassium channel gene. A small region of human KV1.1 mRNA sequence directs efficient modification of one adenosine by human adenosine deaminase acting on RNA 2 (hADAR2). Mutational analysis shows that this region adopts a hairpin structure. Electrophysiological characterization reveals that the editing event (I/V) profoundly…
215 Citations
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