Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.

@article{Himmel2009ControlOH,
  title={Control of high affinity interactions in the talin C terminus: how talin domains coordinate protein dynamics in cell adhesions.},
  author={Mirko Himmel and Anett Ritter and Sven Rothemund and Bj{\"o}rg V Pauling and Klemens Rottner and Alexandre R Gingras and Wolfgang H. Ziegler},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 20},
  pages={13832-42}
}
In cell-extracellular matrix junctions (focal adhesions), the cytoskeletal protein talin is central to the connection of integrins to the actin cytoskeleton. Talin is thought to mediate this connection via its two integrin, (at least) three actin, and several vinculin binding sites. The binding sites are cryptic in the head-to-rod autoinhibited cytoplasmic form of the protein and require (stepwise) conformational activation. This activation process, however, remains poorly understood, and there… CONTINUE READING

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Control of high affinity interactions in the Talin C terminus : How Talin domains coordinate protein dynamics in cell adhesions

  • M. Himmel, A. Ritter, +4 authors W. H. Ziegler
  • Journal of Biological Chemistry
  • 2009

40389–40398 TalinC Interactions in FAs 13842 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • H. Chen, D. M. Choudhury, S. W. Craig
  • J. Biol. Chem
  • 2006

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