Control of herpetic stromal keratitis using CTLA4Ig fusion protein.

  title={Control of herpetic stromal keratitis using CTLA4Ig fusion protein.},
  author={Sreeramaiah N. Gangappa and Elanchezhiyan Manickan and Barry T Rouse},
  journal={Clinical immunology and immunopathology},
  volume={86 1},
Herpetic stromal keratitis (HSK) is an immunoinflammatory lesion in the cornea of the eye set off by infection with herpes simplex virus (HSV). The disease appears to be orchestrated by CD4+ T cells of the Th1 phenotype but the identity of target antigens involved in HSK remains unknown. In this proposal, we investigated if the inhibition of T cell activation with the fusion protein CTLA4Ig would abrogate the disease process when administered systemically. BALB/c mice infected with HSV-1 (RE… CONTINUE READING
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