Control of herpes simplex virus replication is mediated through an interferon regulatory factor 3-dependent pathway.

@article{Menachery2009ControlOH,
  title={Control of herpes simplex virus replication is mediated through an interferon regulatory factor 3-dependent pathway.},
  author={Vineet D Menachery and David A. Leib},
  journal={Journal of virology},
  year={2009},
  volume={83 23},
  pages={12399-406}
}
The type I interferon (IFN) cascade is critical in controlling viral replication and pathogenesis. Recognition pathways triggered by viral infection rapidly induce the type I IFN cascade, often in an IFN regulatory factor 3 (IRF-3)-dependent fashion. This dependence predicts that loss of IRF-3 would render early recognition pathways inoperative and thereby impact virus replication, but this has not been observed previously with herpes simplex virus type 1 (HSV-1) in vitro. In this study, HSV-1… CONTINUE READING
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