Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

  title={Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1},
  author={J. Cliff Yoon and Pere B. Puigserver and Guoxun Chen and Jerry Donovan and Zhidan Wu and James Y Rhee and Guillaume Adelmant and John Stafford and C Ronald Kahn and Daryl K. Granner and Christopher B. Newgard and Bruce M. Spiegelman},
Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the liver. Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus. Here we show that the transcriptional coactivator PGC-1 is strongly induced in liver in fasting mice and in three mouse models of insulin action deficiency: streptozotocin-induced diabetes, ob/ob genotype and liver insulin-receptor knockout. PGC-1 is induced… CONTINUE READING
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