Control of hepatic carbohydrate metabolism and haemodynamics in perfused rat liver by arterial and portal angiotensin II.


DESIGN Angiotensin II (AII; 0.2, 5 and 25 nM) was infused during a single-pass perfusion of a rat liver via both the hepatic artery and the portal vein (portal or arterial AII). Infusion occurred both in the absence and in the presence of the AT1-receptor-antagonist losartan (1 and 10 microM). METABOLISM Arterial and portal AII increased glucose output… (More)


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