Control of growth and differentiation of human neuronal and hematopoietic tumour cells via Myc/Max/Mad-network proteins

@inproceedings{Cetinkaya2005ControlOG,
  title={Control of growth and differentiation of human neuronal and hematopoietic tumour cells via Myc/Max/Mad-network proteins},
  author={Cihan Cetinkaya},
  year={2005}
}
The Myc/Max/Mad transcription factor network regulates a large number of genes involved in cell growth, differentiation and apoptosis. Myc activates and Mad represses and overlapping set of growth-promoting genes, and the network therefore seems to act as a molecular switch between growth and differentiation. Deregulation of myc–family genes occurs frequently in human cancers and is often associated with poor prognosis. One aim of this thesis was to identify negative growth signals affecting… CONTINUE READING

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