Control of glycogen synthesis by glucose, glycogen, and insulin in cultured human muscle cells.

@article{Halse2001ControlOG,
  title={Control of glycogen synthesis by glucose, glycogen, and insulin in cultured human muscle cells.},
  author={Reza Halse and Sylvie Bonavaud and Jane L. Armstrong and James G. McCormack and Stephen J. Yeaman},
  journal={Diabetes},
  year={2001},
  volume={50 4},
  pages={720-6}
}
A key feature of type 2 diabetes is impairment in the stimulation of glycogen synthesis in skeletal muscle by insulin. Glycogen synthesis and the activity of the enzyme glycogen synthase (GS) have been studied in human myoblasts in culture under a variety of experimental conditions. Incubation in the absence of glucose for up to 6 h caused an approximately 50% decrease in glycogen content, which was associated with a small decrease in the fractional activity of GS. Subsequent reincubation with… CONTINUE READING