Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice.

@article{Zhang2007ControlOG,
  title={Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice.},
  author={Hongmei Zhang and Hong-Yi Zhou and Shao-rui Chen and Dinesh Ratan Gautam and Juergen Wess and H. I. Pan},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={323 3},
  pages={963-71}
}
Muscarinic acetylcholine receptors (mAChRs) play an important role in the tonic regulation of nociceptive transmission in the spinal cord. However, how mAChR subtypes contribute to the regulation of synaptic glycine release is unknown. To determine their role, glycinergic spontaneous inhibitory postsynaptic currents (sIPSCs) were recorded in lamina II neurons by using whole-cell recordings in spinal cord slices of wild-type (WT) and mAChR subtype knockout (KO) mice. In WT mice, the mAChR… CONTINUE READING

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Opposing functions

  • HM Zhang, SR Chen, M Matsui, D Gautam, J Wess, HL Pan
  • 2006
Highly Influential
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