Control of genome stability by SLX protein complexes.

  title={Control of genome stability by SLX protein complexes.},
  author={J. Rouse},
  journal={Biochemical Society transactions},
  volume={37 Pt 3},
  • J. Rouse
  • Published 2009
  • Biology, Medicine
  • Biochemical Society transactions
  • The six Saccharomyces cerevisiae SLX genes were identified in a screen for factors required for the viability of cells lacking Sgs1, a member of the RecQ helicase family involved in processing stalled replisomes and in the maintenance of genome stability. The six SLX gene products form three distinct heterodimeric complexes, and all three have catalytic activity. Slx3-Slx2 (also known as Mus81-Mms4) and Slx1-Slx4 are both heterodimeric endonucleases with a marked specificity for branched… CONTINUE READING
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