Control of genome stability by SLX protein complexes.

@article{Rouse2009ControlOG,
  title={Control of genome stability by SLX protein complexes.},
  author={J. Rouse},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 3},
  pages={
          495-510
        }
}
  • J. Rouse
  • Published 2009
  • Biology, Medicine
  • Biochemical Society transactions
  • The six Saccharomyces cerevisiae SLX genes were identified in a screen for factors required for the viability of cells lacking Sgs1, a member of the RecQ helicase family involved in processing stalled replisomes and in the maintenance of genome stability. The six SLX gene products form three distinct heterodimeric complexes, and all three have catalytic activity. Slx3-Slx2 (also known as Mus81-Mms4) and Slx1-Slx4 are both heterodimeric endonucleases with a marked specificity for branched… CONTINUE READING
    Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
    • 307
    GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.
    • 114
    • Highly Influenced
    • PDF
    Mammalian BTBD12 (SLX4) Protects against Genomic Instability during Mammalian Spermatogenesis
    • 52
    • PDF
    Degringolade, a SUMO‐targeted ubiquitin ligase, inhibits Hairy/Groucho‐mediated repression
    • 59
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 178 REFERENCES
    ATM and related protein kinases: safeguarding genome integrity
    • 2,502
    • PDF
    Mechanism of eukaryotic homologous recombination.
    • 1,278
    • PDF
    ATR: an essential regulator of genome integrity
    • 1,484
    • PDF