Control of gastric acid secretion in health and disease.

@article{Schubert2008ControlOG,
  title={Control of gastric acid secretion in health and disease.},
  author={Mitchell L. Schubert and David A. Peura},
  journal={Gastroenterology},
  year={2008},
  volume={134 7},
  pages={
          1842-60
        }
}
Recent milestones in the understanding of gastric acid secretion and treatment of acid-peptic disorders include the (1) discovery of histamine H(2)-receptors and development of histamine H(2)-receptor antagonists, (2) identification of H(+)K(+)-ATPase as the parietal cell proton pump and development of proton pump inhibitors, and (3) identification of Helicobacter pylori as the major cause of duodenal ulcer and development of effective eradication regimens. This review emphasizes the importance… Expand
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