Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.

@article{Thein2009ControlOF,
  title={Control of fetal hemoglobin: new insights emerging from genomics and clinical implications.},
  author={Swee Lay Thein and Stephan Menzel and Mark Lathrop and Chad Garner},
  journal={Human molecular genetics},
  year={2009},
  volume={18 R2},
  pages={R216-23}
}
Increased levels of fetal hemoglobin (HbF, alpha(2)gamma(2)) are of no consequence in healthy adults, but confer major clinical benefits in patients with sickle cell anemia (SCA) and beta thalassemia, diseases that represent major public health problems. Inter-individual HbF variation is largely genetically controlled, with one extreme caused by mutations involving the beta globin gene (HBB) complex, historically referred to as pancellular hereditary persistence of fetal hemoglobin (HPFH… CONTINUE READING