Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element.

@article{Ashcroft2004ControlOE,
  title={Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element.},
  author={Felicity J Ashcroft and Andrea Varr{\'o} and Rod Dimaline and Graham J. Dockray},
  journal={The Biochemical journal},
  year={2004},
  volume={381 Pt 2},
  pages={397-403}
}
The expression of members of the Reg family of secreted lectin-like proteins is increased in response to stress, inflammation and damage in many tissues. In the stomach, Reg is located in enterochromaffin-like cells, where its expression is stimulated by the gastric hormone gastrin. We have examined the mechanisms by which gastrin stimulates expression of Reg-1. Deletional mutations of 2.1 to 0.1 kb of the rat Reg-1 promoter in a luciferase reporter vector were transiently transfected into… CONTINUE READING

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