Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice

  title={Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice},
  author={F. Benninger and T. Freund and N. H{\'a}jos},
  journal={Neurochemistry International},
  pages={89 - 94}
  • F. Benninger, T. Freund, N. Hájos
  • Published 2008
  • Biology, Medicine
  • Neurochemistry International
  • Several studies have shown that capsaicin could effectively regulate excitatory synaptic transmission in the central nervous system, but the assumption that this effect is mediated by TRPV1 vanilloid receptors (TRPV1Rs) has not been tested directly. To provide direct evidence, we compared the effect of capsaicin on excitatory synapses in wild type mice and TRPV1R knockouts. Using whole-cell patch-clamp techniques, excitatory postsynaptic currents (EPSCs) were recorded in granule cells of the… CONTINUE READING
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