Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.

@article{Magliozzi2013ControlOE,
  title={Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.},
  author={Roberto Magliozzi and Teck Y Low and Bart G M W Weijts and Tianhong Cheng and Emma Spanjaard and Shabaz Mohammed and Anouk van Veen and Huib Ovaa and Johan de Rooij and Fried J. T. Zwartkruis and J. L. Bos and Alain de Bruin and Albert J. R. Heck and Daniele Guardavaccaro},
  journal={Developmental cell},
  year={2013},
  volume={27 5},
  pages={574-85}
}
Epithelial cell migration is crucial for the development and regeneration of epithelial tissues. Aberrant regulation of epithelial cell migration has a major role in pathological processes such as the development of cancer metastasis and tissue fibrosis. Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-β and casein kinase-1α and consequently degraded by the proteasome via the SCF(βTrCP… CONTINUE READING
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