Control of dolichyl phosphoglucose formation in human liver microsomes. Kinetic and inhibition studies of nucleosides, nucleotides and analogues of UDPglucose.


A bisubstrate kinetic analysis of UDPglucose:dolichylphosphate glucosyltransferase from human liver microsomes has been carried out which indicated that the kinetics follow a sequential mechanism. Inhibition studies with nucleosides, nucleotides and analogues of the substrate UDPglucose revealed that the nucleoside moiety of UDPglucose, uridine, appears to… (More)


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