Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones.

@article{Ishii2002ControlOD,
  title={Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones.},
  author={Yuki Ishii and Yuko Hori and Shingo Sakai and Yoshio Honma},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={2002},
  volume={13 1},
  pages={19-26}
}
We examined the effects of various adenine analogues on the growth and differentiation of human myeloid leukemia HL-60 cells. Some of these analogues inhibit growth and induce nitroblue tetrazolium reducing activity in HL-60 cells. Cytokinins such as kinetin, isopentenyladenine, and benzyladenine were very effective in inducing nitroblue tetrazolium reduction and morphological changes in the cells into mature granulocytes. On the other hand, cytokinin ribosides such as kinetin riboside… CONTINUE READING

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