Control of developmental transcription factor sigma F by sporulation regulatory proteins SpoIIAA and SpoIIAB in Bacillus subtilis.

@article{Schmidt1990ControlOD,
  title={Control of developmental transcription factor sigma F by sporulation regulatory proteins SpoIIAA and SpoIIAB in Bacillus subtilis.},
  author={Radomir Schmidt and P S Margolis and Leonard Duncan and R Coppolecchia and Charles P. Moran and Richard Losick},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 23},
  pages={9221-5}
}
The sporulation operon spoIIA of Bacillus subtilis consists of three cistrons called spoIIAA, spoIIAB, and spoIIAC. Little is known about the function of spoIIAA and spoIIAB, but spoIIAC encodes a sigma factor called sigma F, which is capable of directing the transcription in vitro of genes that are expressed in the forespore chamber of the developing sporangium. We now report that the products of the spoIIA operon constitute a regulatory system in which SpoIIAA is an antagonist of SpoIIAB (or… CONTINUE READING