Control of dendritic cell differentiation by angiotensin II.

  title={Control of dendritic cell differentiation by angiotensin II.},
  author={Karen Amelia Nahmod and M{\'o}nica Vermeulen and Silvina Raiden and Gabriela Ver{\'o}nica Salamone and Romina Gamberale and Paula X. Fernandez-Calotti and Azucena Laura Alvarez and V{\'i}ctor E. Nahmod and Mirta Nilda Giordano and Jorge Ra{\'u}l Geffner},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={17 3},
Here we analyze the role of the angiotensinergic system in the differentiation of dendritic cells (DC). We found that human monocytes produce angiotensin II (AII) and express AT1 and AT2 receptors for AII. DC differentiated from human monocytes in the presence of AT1 receptor antagonists losartan or candesartan show very low levels of CD1a expression and poor endocytic and allostimulatory activities. By contrast, DC differentiation in the presence of either the AT2 receptor antagonist PD 123319… CONTINUE READING
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