Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability.

@article{Ke2005ControlOD,
  title={Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability.},
  author={Po-Yuan Ke and Yuan-Yeh Kuo and C J Hu and Z T Chang},
  journal={Genes & development},
  year={2005},
  volume={19 16},
  pages={1920-33}
}
Anaphase promoting complex/cyclosome (APC/C)-mediated proteolysis is essential for chromosome segregation, mitotic exit, and G1 entry. Here, we show the importance of APC/C in the control of dTTP pool size in mammalian cells. Two enzymes, thymidine kinase 1 (TK1) and thymidylate kinase (TMPK), involved in dTTP formation are the targets of the APC/C pathway. We demonstrate that TMPK is recognized and degraded by APC/C-Cdc20/Cdh1-mediated pathways from mitosis to the early G1 phase, whereas TK1… CONTINUE READING