Control of cytoplasmic maturation events by cytomegalovirus tegument protein pp150.

@article{Tandon2008ControlOC,
  title={Control of cytoplasmic maturation events by cytomegalovirus tegument protein pp150.},
  author={Ritesh Tandon and Edward S. Mocarski},
  journal={Journal of virology},
  year={2008},
  volume={82 19},
  pages={9433-44}
}
Cytomegalovirus replication depends upon a betaherpesvirus-conserved 150-kDa tegument phosphoprotein (pp150; encoded by UL32) that supports the final steps in virion maturation at cytoplasmic assembly compartments. Amino acid substitutions were introduced into conserved region 1 (CR1) and CR2 of pp150, affecting a region that may interact with nucleocapsids. Two independent CR2 point mutants (N201A and G207A) failed to support viral replication in evaluations by a transient complementation… CONTINUE READING