Control of cullin-ring ubiquitin ligase activity by nedd8.

  title={Control of cullin-ring ubiquitin ligase activity by nedd8.},
  author={Raymond J Deshaies and Ethan D. Emberley and Anjanabha Saha},
  journal={Sub-cellular biochemistry},
The Cullin-RING ubiquitin ligase (CRL) family, which may number as many as 350 different enzymes, has an enormous impact on cellular regulation. CRL enzymes regulate cell biology by conjugating ubiquitin onto target proteins that are involved in a multitude of processes. In most cases this leads to degradation of the target, but in some cases CRL-dependent ubiquitination acts as a switch to activate or repress target function. The ubiquitin ligase activity of CRLs is controlled by cycles of… CONTINUE READING