Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.

@article{CervantesBarragan2006ControlOC,
  title={Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.},
  author={Luisa Cervantes-Barragan and Roland Z{\"u}st and Friedemann Weber and Martin Spiegel and Karl Sebastian Lang and Shizuo Akira and Volker Thiel and Burkhard Ludewig},
  journal={Blood},
  year={2006},
  volume={109 3},
  pages={
          1131-7
        }
}
This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not… CONTINUE READING

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