Control of copper status for cancer therapy.

  title={Control of copper status for cancer therapy.},
  author={Vicki L Goodman and George J. Brewer and Sof{\'i}a D. Merajver},
  journal={Current cancer drug targets},
  volume={5 7},
Copper is a trace element which is tightly regulated in mammals and lower animals. Disruptions of copper homeostasis in humans are rare and they cause serious disorders such as Wilson's disease and Menke's disease. Copper plays an important role in promoting physiological and malignant angiogenesis. Formation of new blood vessels by a tumor enables tumor growth, invasion, and metastasis are copper requiring processes. The copper chelator tetrathiomolybdate (TM), which quickly and effectively… CONTINUE READING

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