Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.

@article{Venkateswaran2000ControlOC,
  title={Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha.},
  author={Amudhan Venkateswaran and Bryan A. Laffitte and Sean B. Joseph and Puiying A. Mak and Damien C Wilpitz and Peter A. Edwards and Peter Tontonoz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 22},
  pages={12097-102}
}
LXR alpha is a nuclear receptor that has previously been shown to regulate the metabolic conversion of cholesterol to bile acids. Here we define a role for this transcription factor in the control of cellular cholesterol efflux. We demonstrate that retroviral expression of LXR alpha in NIH 3T3 fibroblasts or RAW264.7 macrophages and/or treatment of these cells with oxysterol ligands of LXR results in 7- to 30-fold induction of the mRNA encoding the putative cholesterol/phospholipid transporter… CONTINUE READING
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