Control of calcium movement in the myocardium.

  title={Control of calcium movement in the myocardium.},
  author={Glenn A. Langer},
  journal={European heart journal},
  volume={4 Suppl H},
A model for calcium (Ca) movement in the course of excitation-contraction of mammalian myocardium is presented. At physiological levels of [Ca]o between 500-700 mumol Ca/kg wet tissue is bound within the sarcolemmal-glycocalyx--most at anionic phospholipid sites. This Ca feeds two systems responsible for influx--the channel under control of protein phosphorylation and the Na-Ca exchanger regulated by the level of [Na]i. Respiring mitochondria are activated for Ca exchange in the presence of a… CONTINUE READING
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