Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function.

@article{Stevens1999ControlOC,
  title={Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function.},
  author={T. Christine Stevens and Judy R. Creighton and William J. Thompson},
  journal={The American journal of physiology},
  year={1999},
  volume={277 1},
  pages={
          L119-26
        }
}
Pulmonary microvascular endothelial cells (PMVECs) form a more restrictive barrier to macromolecular flux than pulmonary arterial endothelial cells (PAECs); however, the mechanisms responsible for this intrinsic feature of PMVECs are unknown. Because cAMP improves endothelial barrier function, we hypothesized that differences in enzyme regulation of cAMP synthesis and/or degradation uniquely establish an elevated content in PMVECs. PMVECs possessed 20% higher basal cAMP concentrations than did… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 60 extracted citations

Myoendothelial gap junctional signaling induces differentiation of pulmonary arterial smooth muscle cells.

American journal of physiology. Lung cellular and molecular physiology • 2011
View 4 Excerpts
Highly Influenced

Gene Therapy for Acute and Acquired Diseases

Springer US • 2001
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function.

Proceedings of the National Academy of Sciences of the United States of America • 1995
View 4 Excerpts
Highly Influenced

Ca(2+)-sensitive adenylyl cyclases.

Advances in second messenger and phosphoprotein research • 1998
View 1 Excerpt

Endothelial Cells

T. Stevens, G. Brough, T. Moore, P. Babal, W. Thompson
Basel: Birkhauser Verlag, • 1998
View 1 Excerpt

Mechanisms of IschemiaReperfusion Injury in the Lung

T. Moore, P. Khimenko, andA. Taylor
1998
View 1 Excerpt

Pathophysiology. Oxford, UK

T. Moore, A. Taylor
1998
View 1 Excerpt

Similar Papers

Loading similar papers…