Control of bioactive corticotropin release from the neuro-intermediate lobe of the rat pituitary in vitro.

@article{Fischer1977ControlOB,
  title={Control of bioactive corticotropin release from the neuro-intermediate lobe of the rat pituitary in vitro.},
  author={Johann L Fischer and Cortney M. Moriarty},
  journal={Endocrinology},
  year={1977},
  volume={100 4},
  pages={1047-54}
}
The purpose of this study was to identify agents capable of regulating the release of biologically active ACTH from the isolated neuro-intermediate lobe of the rat pituitary. Agents found to be potent secretagogues included acetylcholine (100 mug/ml), hypothalamic stalk-median eminence extract (0.33 eq), arginine antidiuretic hormone (100 mU/ml) and serotonin (100 mug/ml). Lower doses of arginine antidiuretic hormone (5.5 mU/ml) and serotonin (2 mug/ml) were ineffective. Dopamine 2 and 5 mug/ml… CONTINUE READING