Control of beta1 integrin function. Localization of stimulatory epitopes.

  title={Control of beta1 integrin function. Localization of stimulatory epitopes.},
  author={John A. Wilkins and Anli Li and H Ni and Dwayne G. Stupack and Chuan Shen},
  journal={The Journal of biological chemistry},
  volume={271 6},
The beta1 integrins can be expressed on the surface of cells in a latent form, which is activated by a variety of stimuli. As an approach to examining the transition to an active receptor, a panel of stimulatory antibodies to beta1 were produced and characterized. These antibodies induced adherence of the T-leukemic cell line Jurkat to collagen and fibronectin. Competitive antibody binding assays indicated the existence of at least three distinct epitope clusters A (B3B11, JB1B, 21C8), B (B44… CONTINUE READING

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